Nov 302012
 

Pertussis which is commonly called whooping cough is a highly contagious disease that causes uncontrollable, violent coughing. The coughing can make it hard to breathe.  A deep “whooping” sound is often heard when the patient tries to take a breath. While whooping cough can affect people at any age, it can be deadly for infants and young children.

Etiology

It is caused by bacteria known as  Bordetella pertussis which is gram negative, areobic coccobacillus.

Clinical Features

Classic signs of pertussis are a paroxysmal cough, inspiratory whoop, and vomiting after coughing. The cough from pertussis has been documented to cause subconjunctival hemorrhages, rib fractures, urinary incontinence, hernias, post-cough fainting, and vertebral artery dissection.

Different stages Of Disease

1. Incubation period:  is typically seven to ten days in infants or young children, followed by

2. Catarrhal stage : in which there is runny nose, sneezing, low-grade fever and symptoms of the common cold and then finally

3. Paroxysmal stage : characterized by multiple, rapid coughs.

Investigations

The initial diagnosis is usually based on the symptoms. However, when the symptoms are not obvious, pertussis may be difficult to diagnose. In very young infants, the symptoms may be caused by pneumonia instead.

To know for sure, the health care provider may take a sample of mucus from the nasal secretions and send it to a lab, which tests it for pertussis. While this can offer an accurate diagnosis, the test takes some time, and treatment is usually started before the results are ready. Continue reading »

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Nov 162012
 

Tuberculosis causes a major burden on health and economics of low income countries. The delay in diagnosis and inability to cure a high proportion of pulmonary smear positive adult TB cases are the main reasons of increased risk of infection and consequent high mortality in children.

It is important for pediatricians, physicians and related health workers to identify TB in children and manage it accordingly.

What is TB ?

TB is an infectious, systemic, chronic granulomatous disease caused by Mycobacterium tuberculosis. It is an aerobic, non spore forming acid fast bacilli.

Mode Of Infection

Infection occurs almost exclusively through the respiratory  system by inhalation of tubercle bacilli. TB spreads from the primary lung lesion to other parts of the body via blood stream and lymphatics or by direct extension. Majority of children acquire the disease by being exposed to adults with pulmonary infectious TB.

Clinical Features

  • TB may be asymptomatic in as many as 50% of children.
  • Children may present with non specific signs and with minimal or no respiratory symptoms.
  • Cough, fever,anorexia, weight loss, sweating, respiratory distress, lymph adenopathy, wheezing, decreased breath sounds and rales may be seen.
  • A child may have concurrent extra pulmonary involvement as well.

Extra Pulmonary TB

Extra pulmonary TB is defined as those children with AFB smear or culture positive specimen from an extra pulmonary site or a patient with histological and or clinical evidence consistent with active extra-pulmonary TB. In 25% of children with disease TB affects other organs, such as lymph nodes (most common), central nervous system, intestines, pleura, pericardium, bones and joints, genito urinary tract and other parts of the body. Diagnosis is often difficult and should preferably be made by physicians. Extra pulmonary Tb is usually non-infectious.

TB Meningitis 

It is considered as the most serious complication of TB in children because of high mortality and morbidity. It is the most common form of extra pulmonary TB after TB lymphadenitis. It most commonly occurs in children below 5 years of age. . Diagnosis is suspected on clinical grounds and then confirmed on lumbar puncture where CSF shows lymphocytic pleocytosis, high protein and low glucose.  Continue reading »

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Sep 222012
 

Malaria is a disease caused by a Plasmodium parasite that is transmitted through the bite of female Anopheles mosquitoes. A patient with a fever for more than 48 hours in the endemic area should always be suspected for malaria.

Plasmodium Species

Plasmodium is an obligate intracellular protozoa and there are four species that includes:

  • Plasmodium Falciparum: causing the most serious infection with complications.
  • Plasmodium Vivax: have hepatic stages and may cause relapses of infection
  • Plasmodium Ovale: may cause a relapse similar to vivax
  • Plasmodium malariae

Life Cycle of the Parasite

Plasmodium exists in a variety of forms and has a complex life cycle that enables survival in different cellular environments in the human host and the mosquito vector. There are two major phases in the life cycle:

1. Asexual Phase(Schizogony): it occurs in the humans. The Erythrocytic phase of plasmodium asexual development begins when the merozites released from exoerythrocytic schizonts in the liver penetrate erythrocytes. When inside the erythrocyte , the parasite transforms into the ring form, which enlarges to become a trophozite.

2. Sexual Phase(sporogony): it occurs in the mosquito when the mosquito bites an infected human and gets the trophozoites which then complete the sexual cycle and becomes the sporozoite that travels to the salivary glands and can be then transmitted to another human by the mosquito bite.

Mode of transmission

The parasites usually are transmitted to humans by female Anopheles mosquitoes. Malaria can also be transmitted through blood transfusion, via contaminated needles, and transplacentally to a fetus.  Continue reading »

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