Plain Radiography

Plain radiography in anteroposterior and lateral views is the primary and often the only imaging study needed to evaluate a slipped epiphysis. Common radiographic findings include widening and irregularity of the physis, a decrease in epiphyseal height in the center of the acetabulum, a crescent-shaped area of increased density in the proximal portion of the femoral neck, and the “blanch sign of Steel” corresponding to the double density created from the anteriorly displaced femoral neck overlying the femoral head.

In an unaffected patient, the Klein line, a straight line drawn along the superior cortex of the femoral neck on anteroposterior radiograph, intersects the lateral capital epiphysis. As progressive displacement of the epiphysis occurs in SCFE, the amount of the Klein line that intersects the epiphysis decreases, compared with the uninvolved hip, and eventually the line fully misses intersection with the proximal femoral epiphysis . A true lateral (cross-table lateral) radiographic view of the hip better defines the extent of posterior displacement of the femoral epiphysis.

Computed Tomography.

CT can be used to confirm epiphyseal displacement and accurately measure the amount of Continue reading »

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Slipped Capital Femoral Epiphysis is a hip disorder that affects adolescents, most often between 12 and 15 yr of age, and involves the displacement of the CFE from the metaphysis through the zone of hypertrophy layer of the physeal plate.

CLASSIFICATION

SCFE may be classified temporally, according to onset of symptoms (acute, chronic, acute-on-chronic); functionally, according to patient’s ability to bear weight (stable or unstable); or morphologically, as the extent of displacement of the femoral epiphysis relative to the neck (mild, moderate, or severe), as estimated by measurement on radiographic or CT images.

An acute SCFE has been characterized as one occurring in a patient with prodromal symptoms for ?3 wk and should be distinguished from a purely traumatic separation of the epiphysis in a previously normal hip . The patient with an acute slip will usually have some prodromal pain in the groin, thigh, or knee and will usually report a relatively minor injury (a twist or fall) that normally is not as sufficiently violent as to produce an acute fracture of this severity.

Chronic SCFE is the most frequent form of presentation. Typically, an adolescent presents with a few-month history of vague groin, upper thigh, or lower thigh pain and a limp.

The children with acute-on-chronic SCFE may have features of both ends of the spectrum. Prodromal symptoms have been present for >3 wk with a sudden exacerbation of pain.

The stability classification separates patients based on their ability to ambulate and is more useful in predicting prognosis and establishing a treatment plan. The SCFE is considered “stable” when the child is able to walk with or without crutches. A child with an “unstable” SCFE is unable to walk with or without crutches. Patients with unstable SCFEs have a much higher prevalence of Continue reading »

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EPIDEMIOLOGY.

The annual incidence of osteosarcoma in the USA is 5.6 cases per million children <15 yr of age. The highest risk period for development of osteosarcoma is during the adolescent growth spurt, suggesting an association between rapid bone growth and malignant transformation. Patients with osteosarcoma are taller than their peers of similar age.

PATHOGENESIS.

Although the cause of osteosarcoma is unknown, certain genetic or acquired conditions predispose patients to development of osteosarcoma.

Patients with hereditary retinoblastoma have a significantly increased risk of developing osteosarcoma. The sites of osteosarcoma in these patients initially were thought to be located only in previously irradiated areas, but more recently they have been shown to arise in sites far from the radiation field. Predisposition to development of osteosarcoma in these patients may be related to loss of heterozygosity of the RB gene.

Osteosarcoma also occurs in the Li-Fraumeni syndrome, which is a familial cancer syndrome associated with germline mutations of the p53 gene.

The pathologic diagnosis of osteosarcoma is made by demonstration of a highly malignant, pleomorphic, spindle cell neoplasm associated with the formation of malignant osteoid and bone. Continue reading »

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