Cerebral palsy (CP) is a term used to describe a diverse group of chronic, nonprogressive disorders of movement, posture, and tone resulting from a central nervous system insult during early development. The timing of the insult may be prior to, at the time of, or shortly after birth.
Etiology
Many factors, both genetic and acquired, have been postulated as causes of cerebral palsy. These include hypoxic-ischemic injury, structural malformations, vascular disorders, intraventricular or subarachnoid hemorrhage, infections, hormonal disorders, toxins, trauma, metabolic disease, prematurity, and hemolytic disease of the newborn. In recent years, several studies have sought to determine the relative contribution of these and other factors to the total incidence of cerebral palsy.
Perinatal Asphyxia
Historically, asphyxia during labor and delivery has been implicated as a major cause of cerebral palsy. In the last decade, a number of large population studies have revealed that asphyxia probably accounts for only a relatively small proportion of cases. The rate is approximately 4 times higher (16.7 versus 4.7) if the Apgar score is 0 to 3 at 10 minutes compared with 5 minutes. It is remarkable that even when the Apgar score was less than or equal to 3 for 15 minutes, the majority of infants did not develop cerebral palsy.When the association of CP with a variety of potentially asphyxiating conditions was examined, only a tight nuchal cord was associated with a statistically significant increase in risk. Thus, these three major studies are all in agreement that birth asphyxia causes fewer than 1 in 5, and probably fewer than 1 in 10, of the cases of cerebral
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