Dec 042010
 
The first goal of imaging the urinary tract is to discover abnormalities that either may be risk factors for UTI or may preclude prompt response to therapy. These risk factors include vesicoureteral reflux or voiding dysfunction, and factors that complicate therapy include partial ureteropelvic junction obstruction or cystic kidney disease. The second goal of imaging is to monitor renal growth and detect scarring.
Determining which children to evaluate, which tests are most appropriate, and when to obtain studies is critical to develop a rationalĀ and consistent approach to this controversial component of UTI.
For a long time, majority opinion favored imaging evaluation of the upper and lower urinary tract in every child following a well-documented first UTI.
(1) All patients with documented UTI should have ultrasound to assess integrity of the urinary tract;
(2) VCUG should be obtained in all patients less than 3 years of age and all patients with or suspected of having pyelonephritis;
(3) No further studies if ultrasound is normal in children older than 3 years or with minimal symptoms at presentation.
There are several reasons for routinely imaging infants and young children with UTI:
(1) a high incidence of VUR is found in this age group, approaching 35 to 50% (70% in children <1 year);
(2) renal scarring following infection is most likely to occur in the first 2 to 4 years of life; and
(3) symptoms are so vague that differentiation between upper and lower tract infection is usually Continue reading »
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Aug 182010
 

Hemolytic-uremic syndrome (HUS), first described in 1955, is a heterogeneous syndrome characterized by a triad of microangiopathic hemolytic anemia, acute renal failure, and thrombocytopenia. Initially thought to be a sporadic process, it is now recognized as the most common cause of acute renal failure in children.

Pathogenesis:

In D+ HUS, with Shiga toxin-producing E. coli O157:H7 infection, the toxin binds, invades, and causes destruction of colonic epithelial cells, resulting in bloody diarrhea. Presumably because of the inflamed colon allowing transmural absorption, the toxin then enters the blood circulation. There the toxin binds to a glycolipid receptor known as globotriaosylceramide (Gb3), which results in endocytosis of the toxin usually within renal glomerular endothelial cells, and at times, other target organs. The expression of Gb3 receptors appears to be higher in infants and young children, which may in part explain the age-related propensity for developing HUS. Older children and adults have lower numbers of these receptors but may develop HUS whenever the combined effect of lipopolysaccharide and cytokines upregulate the expression of these Gb3 receptors.

Clinical Features:

With STEC infection, the incubation period is typically 3 to 4 days after exposure (range, 1 to 14 days).

Initial signs of symptomatic infection are vomiting, diarrhea, and significant abdominal pain. The diarrhea is often watery like typical viral gastroenteritis Continue reading »

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May 212010
 

Primary reflux is a congenital abnormality of the normally oblique insertion of the ureter through the bladder wall at the ureterovesical junction and is not associated with urinary tract or other congenital anomalies. Primary VUR usually resolves spontaneously during the first decade. Although the likelihood of resolution exceeds 80% when the VUR is mild, discovered in the first year of life, and unilateral, even the most severe reflux has a 40 to 50% spontaneous resolution rate. Patients with primary reflux rarely develop significant clinical sequelae such as proteinuria, hypertension, or renal insufficiency.

Secondary reflux develops from elevated intravesicular pressure that may result from abnormal voiding patterns or anomalies, including urinary tract obstruction. In one cause of Continue reading »
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