Red Blood Cells ( RBCs )
Indicated in cases of severe anemia usually when Hb is < 7 gm%. or when there is acute , severe, traumatic blood loss.
Different types include:
- Whole Blood ( rarely used )
- Packed RBCs = whole blood less 70% of plasma , most commonly used
- Leukocyte poor RBCs= for pateints with history of febrile reaction to blood products or who will recieve many transfusions
- Washed RBCs = to prevent host-versus graft disease in Ig A deficient recepients
Used when there is a potential for a clotting disorder due to thrombocytopenia ( platelets<10,000 or < 20,000 when surgery is planned ). indicated also in cases of clinically significant quantitative platelet defect.
Available products include:
- Fresh frozen plsma (FFP )
- Single donor palsma
Indicated when there is an intravascular fluid depletion, not responsive to crystalloid or bleeding due to depletion of clotting factors.
Clotting Factor Concentrate
- Cryoprecipitate has high levels of factor VIII, von willebrand factor and fibrinogen
- Genetically Engineered factor VIII concentrates only for factor VIII defiecency.
- Vitamin K dependent factor concentrate has factors II, VII, IX, X and protein C and S
Indicated for factor deficiencies or acute liver failure .
Non specific gamma globulins and intravenous gamma globulin (IVIG ) used in diseases like Guillain Barre or kawasaki disease.