Jan 152011
 
  • Electrocardiography is critical in the diagnosis of electrical disorders of the heart. It may serve as a useful screening tool in the evaluation of patients of suspected structural defects or abnormalities of the myocardium.
  • Newborns have a large variability in electrocardiogram (ECG) voltages and intervals due in large part to hemodynamic and myocardial adaptations that are needed once the placenta is no longer part of the circulatory system.
  • Changes continue, albeit at a slower pace, from infancy through adolescence.
  • Algorithms used to interpret ECGs in adults cannot be used in children. This section is a basic, although incomplete, guide to the pediatric ECG.
Rate
  • The usual recording speed is 25 mm/sec; each little box (1 mm) is 0.04 seconds and each big box (5 mm) is 0.2 seconds.
  • With a fast heart rate, count the R-R cycles in 6 large boxes (1.2 seconds) and multiply by 50.
  • With a slow heart rate, count the number of large boxes between R waves and divide into 300 (1 box = 300, 2 boxes = 150, 3 boxes = 100, 4 boxes = 75).
  • Table below lists normal heart rates.
Rhythm
  • Are the QRS deflections regular? Variation in the rate up and down in concert with respirations is normal (sinus arrhythmia) and can be pronounced in young healthy hearts.
  • Irregular QRS pattern suggests the possibility of an atrial arrhythmia. With pauses and narrow QRS, look for evidence of atrial premature contractions with P waves of different of appearance and/or axis as compared with sinus beats. The early P wave may not conduct, leading to longer pauses (blocked atrial premature contractions).
  • The QRS may be prolonged if conduction down the atrioventricular (AV) node is delayed (aberrant conduction). Wide QRS complexes with pauses may represent premature contractions from a ventricular focus, especially if the T-wave morphology is also altered Continue reading »
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Jan 112011
 
Epidemiology
  • Animals most commonly associated with the transmission of rabies infection include bats, skunks, raccoons, and foxes.
  • Rabies is rarely or never transmitted by squirrels, chipmunks, rats, mice, guinea pigs, gerbils, hamsters, or rabbits.
Clinical Presentation
  • Prodromal phase (2–10 days): fever, headache, photophobia, anorexia, sore throat, musculoskeletal pain, itching, pain, and tingling at the site of the bite
  • Acute neurologic phase (2–30 days): delirium, paralysis, hydrophobia, coma, and respiratory arrest
Laboratory Studies
  • The virus may be isolated from the saliva, and viral nucleic acid may be detected in infected tissues.
  • Antibody may be detected in the serum or CSF.
  • Diagnosis may also be based on fluorescent microscopy on a skin biopsy specimen from the nape of the neck.
Treatment
  • Scratches or bites should be thoroughly irrigated with soap and water.
  • Postexposure prophylaxis should ideally be given within 24 hours of the exposure.
    • Rabies vaccine is given intramuscularly (1.0 mL) in the deltoid area or anterolateral aspect of the thigh, on day 0 and repeated on days 3, 7, 14, and 28.
    • Rabies immune globulin (RIG) should be given concurrently with the first dose of vaccine. The recommended dose is 20 IU/kg; as much of the dose as possible should be used to infiltrate the wound and the remainder should be given intramuscularly. Continue reading »
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Jan 082011
 
Definitions
  • Hyponatremia is defined as a serum sodium of <135 mEq/L.
  • Water intoxication is defined as an “acute neurologic disturbance that results from rapid, excessive water intake.” The associated rapid decrease in sodium can result in lethargy, seizures, coma, and death.
Epidemiology and Etiology
  • Forty percent of children in children’s hospitals have a serum sodium of <135 mEq/L as a result of chronic illness. They are asymptomatic and do not require special intervention.
  • Causes of water intoxication include excessive parenteral or enteral water administration by medical personnel, excessive oral ingestion of water in an infant, repeated immersion, and excessive voluntary oral ingestion of water.
  • During a review of 34 patients with water intoxication at St. Louis Children’s Hospital between January 1975 and July 1990, investigators found that excessive water was usually ingested with a bottle. There were multiple reasons given for giving the infants excessive water, including “ran out of formula, gave water for diarrhea, and gave water for irritability or fussiness.”
Clinical Presentation and Physical Examination
  • Clinical presentation: 3- to 6-month-old infant who presents with apnea or seizures
  • Physical examination
    • Careful neurologic examination, including evaluating mental status
    • Low body temperature despite warm summer environment

Treatment
  • Central pontine myelinolysis occurs from rapid correction of chronic hyponatremia. The Continue reading »
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