Sep 302010
 

Although many skin disorders are easily recognized by simple inspection, the history and physical examination are often necessary for accurate assessment. The entire body surface, mucous membranes, conjunctiva, hair, and nails should always be examined thoroughly under adequate illumination. The color, turgor, texture, temperature, and moisture of the skin and the growth, texture, caliber, and luster of the hair and nails should be noted. Skin lesions should be palpated, inspected, and classified on the bases of morphology, size, color, texture, firmness, configuration, location, and distribution. One must also decide whether the changes are those of the primary lesion itself or whether the clinical pattern has been altered by a secondary factor such as infection, trauma, or therapy.

Primary lesions are classified as macules, papules, patches, plaques, nodules, tumors, vesicles, bullae, pustules, wheals, and cysts.

A macule represents an alteration in skin color but cannot be felt.

When the lesion is >1 cm, the term patch is used.

Papules are palpable solid lesions <0.5–1 cm, whereas nodules are larger in diameter.

Tumors are usually larger than nodules and vary considerably in mobility and consistency. Vesicles are raised, fluid-filled lesions <0.5 cm in diameter; when larger, they are called bullae. Pustules contain purulent material.

Wheals are flat-topped, palpable lesions of variable size, duration, and configuration that Continue reading »

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 Posted by at 3:40 am  Tagged with:
Sep 272010
 

Folate exists in a number of different chemical forms. Folic acid (pteroylglutamic acid) is the synthetic form used in fortified foods and supplements. Naturally occurring folates in foods (pteroylpolyglutamate) are not used as well as folic acid. Folate coenzymes are involved in a variety of reactions, including synthesis of deoxyribonucleic acid and purine, amino acid interconversion, and conversion of homocysteine to methionine. Because of its role in protein synthesis, the risk of deficiency is increased during periods of rapid growth or increased cellular metabolism.

Impaired folate status may be associated with long-term drug treatment of various non-neoplastic diseases, including the use of high-dose nonsteroidal anti-inflammatory drugs; the anticonvulsants diphenylhydantoin and phenobarbital; and methotrexate used in the treatment of rheumatoid arthritis, psoriasis, asthma, and inflammatory bowel disease.

Folate deficiency may result from poor nutrient intake or poorly prepared foods ; malabsorption (hereditary folate malabsorption, celiac disease, inflammatory bowel disease, alcoholism); diseases with a high cell turnover rate (sickle cell anemia, psoriasis); inborn errors of folate metabolism (methylene tetrahydrofolate reductase, methionine synthase reductase, glutamate formiminotransferase deficiencies) ; or autoantibodies against the cerebral folate receptor in the choroid plexus.

Anemia

Anemia due to decreased folate intake usually becomes manifest under clinical conditions that have increased vitamin requirements (e.g., pregnancy, growth in infancy, chronic hemolysis). The normal infant daily requirement is 25–35?g/day. The anemia is macrocytic (mean corpuscular Continue reading »

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Sep 172010
 

Kawasaki disease (KD), formerly known as mucocutaneous lymph node syndrome and infantile polyarteritis nodosa, is an acute febrile vasculitis of childhood.

Kawasaki disease is the leading cause of acquired heart disease in children in the United States and Japan.

Fever is characteristically high (104°F or higher), remittent, and unresponsive to antibiotics. The duration of fever without treatment is generally 1–2 wk, but it may persist for 3–4 wk. Prolonged fever is prognostic for the development of coronary artery disease.

In addition to fever, the five characteristic features of Kawasaki disease are: bilateral bulbar conjunctival injection, usually without exudate; erythema of the oral and pharyngeal mucosa with strawberry tongue and dry, cracked lips, and without ulceration; edema and erythema of the hands and feet; rash of various forms (maculopapular, erythema multiforme, or scarlatiniform) with accentuation in the groin area; and nonsuppurative cervical lymphadenopathy, usually unilateral, with node size of ?1.5 cm.

Perineal desquamation is common in the acute phase. Periungual desquamation of the fingers and toes begins 1–3 wk after the onset of illness and may progress to involve the entire hand and foot.

Other features include extreme irritability that is especially prominent in infants, aseptic meningitis, diarrhea, mild hepatitis, hydrops of the gallbladder, urethritis and meatitis with sterile pyuria, otitis media, and arthritis. Arthritis may occur early in the illness or may develop in the 2nd–3rd week, generally affecting hands, knees, ankles, or hips. It is self-limited but may persist Continue reading »

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